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Mito-TEMPO is a mitochondria-targeted superoxide dismutase mimetic with superoxide and alkyl radical scavenging properties. It significantly reduces the increase in ALT activities and areas of necrosis, indicating sustained protection during acetaminophen-induced hepatotoxicity. Mito-TEMPO can also induce secondary apoptosis in the late phase of APAP hepatotoxicity by inhibiting RIP3.
Mitochondria-targeted
Superoxide dismutase mimetic
Superoxide and alkyl radical scavenging properties
Attenuates increases in ALT activities and reduces necrosis areas in acute liver injury
Induces secondary apoptosis in APAP hepatotoxicity via RIP3 inhibition
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Rhodamine B isothiocyanate (RBITC) is a fluorescent dye bearing an isothiocyanate functional group enabling its covalent conjugation specifically to amino groups in proteins and peptides Upon excitation by green light wavelengths this compound emits characteristic orange-red fluorescence allowing for visualization and detection of labeled biomolecules in cellular and tissue samples Due to its stable covalent binding to target proteins RBITC is employed extensively in fluorescence microscopy immunohistochemical analysis and in vitro labeling studies in disciplines such as cell biology neuroscience and immunology Its chemical structure facilitates selective attachment aiding the detailed investigation of cellular localization protein dynamics and molecular interactions in biological systems
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Also available in 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Mito-TEMPO is a mitochondria-targeted superoxide dismutase mimetic. Mito-TEMPO with superoxide and alkyl radical scavenging properties. purity: 98%
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1-Isothiocyanato-PEG4-alcohol is a PEG-based PROTAC linker designed for the synthesis of PROTACs. PROTACs (Proteolysis Targeting Chimeras) are innovative small molecules composed of two distinct ligands connected by a linker: one ligand binds to an E3 ubiquitin ligase, and the other targets a protein of interest. This unique design enables PROTACs to leverage the intracellular ubiquitin-proteasome system for the selective degradation of target proteins, offering a promising approach for developing targeted therapy drugs.
Molecular weight: 235.30
Appearance: Colorless to light yellow liquid
Application: PROTAC linker for the synthesis of PROTACs
Utilizes the ubiquitin-proteasome system for selective degradation of target proteins
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4-Methoxyphenyl isothiocyanate is an organic research reagent used as an electrophilic isothiocyanate building block for synthesis and derivatization. It is supplied in small laboratory quantities and should be handled and stored according to the safety data sheet.
Electrophilic isothiocyanate for introducing thiourea and related motifs.
Useful building block for small-molecule synthesis and derivatization.
Applicable in medicinal chemistry and reagent screening workflows.
Small, easy-to-handle 5 g laboratory package.
Handle per SDS recommendations; use appropriate personal protective equipment.
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3-Acetylphenyl acetate is an aromatic acetyl ester used as a pharmaceutical intermediate and research reagent. It has the molecular formula C10H10O3 and a molecular weight of 178.19 g/mol, and is supplied at high purity for laboratory synthesis and development.
High purity suitable for research applications.
Useful as a pharmaceutical intermediate in organic synthesis.
Defined molecular formula C10H10O3 and molecular weight 178.19 g/mol.
Available in small pack sizes for laboratory use.
Typically supplied with a certificate of analysis and safety data sheet.
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